This volume contains contributions based on selected presentation at the CwU2007 workshop. The workshop aimed at contributing to a better understanding between practitioners dealing with the safety of complex systems under uncertainty, and scientists working on either corresponding modeling approaches, or on methods that can be adapted for improving the understanding and management of uncertainty. The focus of the CwU 2007 was on novel approaches to supporting robust decision-making and design, especially when uncertainty is irreducible, consequences might be enormous, and the decision process involves stakeholders with diverse interests. --P. v-vi